A-Kinase-Anchoring Protein–Lbc Connects Stress Signaling to Cardiac Hypertrophy
نویسندگان
چکیده
منابع مشابه
A-kinase-anchoring protein-Lbc connects stress signaling to cardiac hypertrophy.
Heart failure often occurs as a consequence of persistent trauma to the myocardium. Cardiovascular pathologies, including hypertension, valvular disease, atherosclerosis, and ischemia, can all lead to pressure overload and myocardial dysfunction. In the face of such stressors, the heart attempts to maintain normal contractile function by initiating a complex remodeling process involving the ree...
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The Beta-adrenergic receptors (β-ARs) stimulation enhances contractility through protein kinase-A (PKA) substrate phosphorylation. This PKA signaling is conferred in part by PKA binding to A-kinase anchoring proteins (AKAPs). AKAPs coordinate multi-protein signaling networks that are targeted to specific intracellular locations, resulting in the localization of enzyme activity and transmitting ...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2013
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.01490-12